There are several important differences. The practical difference between Lithium batteries and Lithium-ion (Li-ion) batteries is that most Lithium batteries are not rechargeable but Li-ion batteries are rechargeable. From a chemical standpoint Lithium batteries use lithium in its pure metallic form. Li-ion batteries use lithium compounds which are much more stable than the elemental lithium used in lithium batteries. A lithium battery should never be recharged while lithium-ion batteries are designed to be recharged hundreds of times.